Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate almost every biological process. Defects in this homeostatic equilibrium, result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Our…

Post-translational modifications (PTM) by members of the ubiquitin family are at the heart of almost every biological process, including regulation of protein levels, localization, and quality control. Defects in this protein homeostasis (proteostasis) can result in developmental anomalies and disease. An intricate interplay exists among the ubiquitin-family members, with diverse chains and linkages that constitutes a “ubiquitin code”, the full meaning of which is largely…