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1 event,
Druggability of the Ubiquitin System – which road to take?
Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate almost every biological process. Defects in this homeostatic equilibrium, result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Our…
2 events,
Crosstalk between Ub family members under stress conditions
UBICODE & UBIRED TRAINING SESSION MARCH 11-15, 2019 CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE - VALENCIA, ES In this course we will use tools and technologies to determine the modification of substrates with Ub/UbLs, to learn about their specificity, affinity and their applications.. The capacity to capture and identify distinct chains with these tools will be analysed and compared. Strategies include His6 purification, pan or chain-selective molecular…
Training course | CNRS-CIPF | VALENCIA
Crosstalk between Ub family members under stress conditions 11-15 MARCH 2019 Open blog post