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December 2018
1st UBIRED MEETING
It will be the first meeting among UBIred integrating groups. The main aim of the meeting is to introduce the Networking Projects and to present the Working Groups. UBIRed CBMSO, 5 de Diciembre de 2018 Ramón Areces Auditorium PROGRAM 10:00-11:15 Rosa Farràs Targeting the Polyamine-Hypusine axis in cáncer José Luis Rosa Regulation of cell proliferation by the ubiquitin ligase HERC1 Gaël Roue Targeting ubiquitin-proteasome system in aggresive B-cell lymphoma 11:15-11:45 Coffee break 11:45-13:00 Emilio Lecona SUMO, ubiquitin and the Dynamics…
Find out more »February 2019
Druggability of the Ubiquitin System – which road to take?
Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate almost every biological process. Defects in this homeostatic equilibrium, result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Our one-day symposium will therefore focus on the potential developments with regards to the druggability of…
Find out more »March 2019
Crosstalk between Ub family members under stress conditions
UBICODE & UBIRED TRAINING SESSION MARCH 11-15, 2019 CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE - VALENCIA, ES In this course we will use tools and technologies to determine the modification of substrates with Ub/UbLs, to learn about their specificity, affinity and their applications.. The capacity to capture and identify distinct chains with these tools will be analysed and compared. Strategies include His6 purification, pan or chain-selective molecular traps (to capture ubiquitin, SUMO and NEDD8) and chain specific nanobodies and/or minibodies. TRAINERS Dimitris Xirodimas…
Find out more »Training course | CNRS-CIPF | VALENCIA
Crosstalk between Ub family members under stress conditions 11-15 MARCH 2019 Open blog post
Find out more »February 2020
SYMPOSIUM: Writing and editing the Ubiquitin code
Post-translational modifications (PTM) by members of the ubiquitin family are at the heart of almost every biological process, including regulation of protein levels, localization, and quality control. Defects in this protein homeostasis (proteostasis) can result in developmental anomalies and disease. An intricate interplay exists among the ubiquitin-family members, with diverse chains and linkages that constitutes a “ubiquitin code”, the full meaning of which is largely unknown. Fundamental research on the ubiquitin code continues to grow, with the pharmaceutical industry taking…
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