UBIRED

SYMPOSIUM: Writing and editing the Ubiquitin code
2020-02-26 - 2020-02-27 | UPV/EHU Bilbao, Avenida Abandoibarra, 3, Bilbao, Bizkaia, 48009, Spain
Post-translational modifications (PTM) by members of the ubiquitin family are at the heart of almost every biological process, including regulation of protein levels, localization, and quality control. Defects in this protein homeostasis (proteostasis) can result in developmental anomalies and disease. An intricate interplay exists among the ubiquitin-family members, with diverse chains and linkages that constitutes a “ubiquitin code”, the full meaning of which is largely unknown. Fundamental research on the ubiquitin code continues to grow, with the pharmaceutical industry taking aim at potential targets in the proteostasis area for novel therapies.
“Writing and Editing the Ubiquitin Code” is a one-and-a-half day symposium that will focus on how the code is written and edited through ligases and proteases, how the different modifications affect cell signaling, and how new technologies can be applied to analyze these modifications. Presentations will cover a wide range of topics, from genome instability and metabolic regulation, to cancer, neurodegeneration and infectious diseases.
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Training course | CNRS-CIPF | VALENCIA
2019-03-11 - 2019-03-15 | CIPF- Centro de Investigación Príncipe Felipe, C/ Eduardo Primo Yúfera 3, Valencia, Valencia, 46012, Spain
Crosstalk between Ub family members under stress conditions
11-15 MARCH 2019
Open blog post

Crosstalk between Ub family members under stress conditions
2019-03-11 - 2019-03-15 | CIPF- Centro de Investigación Príncipe Felipe, C/ Eduardo Primo Yúfera 3, Valencia, Valencia, 46012, Spain
UBICODE & UBIRED TRAINING SESSION
MARCH 11-15, 2019
CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE – VALENCIA, ES
In this course we will use tools and technologies to determine the modification of substrates with Ub/UbLs, to learn about their specificity, affinity and their applications.. The capacity to capture and identify distinct chains with these tools will be analysed and compared. Strategies include His6 purification, pan or chain-selective molecular traps (to capture ubiquitin, SUMO and NEDD8) and chain specific nanobodies and/or minibodies.
TRAINERS

Dimitris Xirodimas (CNRS-UbiCODE),
Manuel S. Rodriguez (CNRS-UbiCODE),
Laurie Bonnafe (CNRS),
Rosa Farràs (CIPF), Pierre Soule (Nanotemper)

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Druggability of the Ubiquitin System – which road to take?
2019-02-27 | CEDOC (Lisbon) – Auditorium Professor Manuel Machado Macedo, R. Câmara Pestana 6, Lisboa, 1150-078, Portugal
Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate almost every biological process. Defects in this homeostatic equilibrium, result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention.
Our one-day symposium will therefore focus on the potential developments with regards to the druggability of the ubiquitin system. Discussions will cover a wide range of topics, from genome instability and cancer to neurodegeneration, metabolic and infectious diseases.

Call for applications – oral presentations : 2018-09-12 to 2019-01-28
Call for applications – poster presentations : 2018-09-12 to 2019-01-28
Registration deadline: 2018-02-10

1st UBIRED MEETING
2018-12-05 10:00 - 17:00 UTC | Centro de Biología Molecular Severo Ochoa, C/ Nicolás Cabrera nº 1; Campus de la Universidad Autónoma de Madrid, Madrid, Madrid, 28049, Spain
It will be the first meeting among UBIred integrating groups. The main aim of the meeting is to introduce the Networking Projects and to present the Working Groups.
UBIRed
CBMSO, 5 de Diciembre de 2018
Ramón Areces Auditorium
PROGRAM
10:00-11:15
Rosa Farràs
Targeting the Polyamine-Hypusine axis in cáncer
José Luis Rosa
Regulation of cell proliferation by the ubiquitin ligase HERC1
Gaël Roue
Targeting ubiquitin-proteasome system in aggresive B-cell lymphoma
11:15-11:45
Coffee break
11:45-13:00
Emilio Lecona
SUMO, ubiquitin and the Dynamics of DNA Replication
Antonio Galarreta
USP7 couples DNA replication termination to mitotic entry
Jordi Torres
Smc5/6, an atypical structural maintenance of chromosomes complex with two RING-type subunits
13:00-14:30
Lunch Restaurante el Goloso
14:30-15:20
Carmen Rivas
Regulation of the RPL11-MDM2-p53 pathway by SUMO
Timothy T Thomson
Differential DNA damage response associated with alternative splicing of RAP80
15:20-15:50
Coffee Break
15:50-16:40
Mario García Domínguez
Sumo role in neuronal differentiation and ischemia
Jim Sutherland
Better with biotin: new tools for studying the UbL ecosystem
16:40-17:00
Organization of network activities
